Uncharted Biosynthetic Landscapes

Research

Our team is interested in discovering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immunosuppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites.

We also work on involving the general public in helping to source new medicines through citizen science projects.

News

Citizen science

As part of our participatory initiative focused on exploring the potential of soil as a source of novel biosynthetic genes, citizens from across France have generously submitted over 1,500 soil samples.

You can check the first results of the analysis of their biosynthetic genes here:

https://www.sciencealapelle.fr/results

ERC Starting Grant

The European Research Council is now backing our lab ! We are hiring bright minds at all levels to supercharge our natural products discovery approach. Join us in a beautiful space in the heart of Paris and leverage our massive BGC cloning platform to discover new antibiotics and more !

Join the lab now!

Join us in a beautiful space in the heart of Paris and leverage our massive BGC cloning platform designed to discover new antibiotics and active molecules ! We clone BGCs hundreds at a time, express them in model hosts and send them all straight to mass spec and bioassays. Vast uncharted biosynthetic landscapes in front of us…

Send us a CV