Uncharted Biosynthetic Landscapes
Our team is interested in discovering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immunosuppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites.
We also work on involving the general public in helping to source new medicines through citizen science projects.
As part of our participatory initiative focused on exploring the potential of soil as a source of novel biosynthetic genes, citizens from across France have generously submitted over 1,500 soil samples.
You can check the first results of the analysis of their biosynthetic genes here:
ERC Starting Grant
The European Research Council is now backing our lab ! We are hiring bright minds at all levels to supercharge our natural products discovery approach. Join us in a beautiful space in the heart of Paris and leverage our massive BGC cloning platform to discover new antibiotics and more !
Join the lab now!
Join us in a beautiful space in the heart of Paris and leverage our massive BGC cloning platform designed to discover new antibiotics and active molecules ! We clone BGCs hundreds at a time, express them in model hosts and send them all straight to mass spec and bioassays. Vast uncharted biosynthetic landscapes in front of us…
PharmD., PhD. University Paris Cité, Postdoctoral training Rockefeller University
M.Phil. Biotechnology, University of Cambridge
M.Sc. Biotechnology, AgroParisTech
PhD. INSA Lyon
M.Sc. Biotechnology, AgroParistech
PhD. University of Porto / Saarland University
Libis V. et al. Multiplexed mobilization and expression of biosynthetic gene clusters.
Nature Communications, 13, 5256 (2022) doi.org/10.1038/s41467-022-32858-0
Libis V. et al. Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences
Nature Communications, 10, 3848 (2019) doi.org/10.1038/s41467-019-11658-z