WELCOME
to ELiS Laboratories website
The Engaged Life Science (ELiS) Collaboratory
INSERM U1338 (ERL)
ELiS Labs, headed by team leaders Amir Pandi, Vincent Libis (vice director) and Ariel Lindner (director), engages in interdisciplinary research aimed at harnessing fundamental understanding of living systems to face global sustainable development challenges.
We combine expertise in computational biology, systems and synthetic biology and promote open, inclusive, frugal science. Our work is carried out at the INSERM U1338 ERL of INSERM (the French national biomedical institute) and the Sorbonne Université, hosted in and supported by the Learning Planet Institute in Paris.
ELiS combines the expertise of >20 young researchers from >10 nationalities in-house as well as affiliated faculty and alumni across the globe.
Research highlights: Discovery and understanding of novel bioactive microbial metabolites — Natural product discovery from soil bacteria — TerraBacta: global atlas of soil biosynthetic gene clusters — Development of de novo antimicrobial peptides — Engineering bacteria for sustainable bio-production via synthetic organelles – Frugal solutions for low cost detection of infectious agents– Open Medical solutions (e.g., dialysis machine, breast cancer screening)
Discover Our Teams
SEED – Systems Engineering and Evolution Dynamics
UBL – Uncharted Biosynthetic Landscapes
The Libis team is interested in disco-vering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immuno-suppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites.
SynBAI – Synthetic Biology and Artificial Intelligence
The Pandi team research focuses on the development of de novo antimicrobial peptides via a combined approach of machine learning and synthetic biology. Additionally, we use machine learning models to predict and design phase-separating polypeptides and build codon and gene expression language models.
Discover Our Favorite Collaborators
MDM – Molecular Diversity of Microbes
Along this scientific journey, we are glad to count among our favorite collaborators, Aude Bernheim, group leader of the Molecular Diversity of Microbes (MDM) Lab at Institut Pasteur. MDM lab research focuses on anti-phage immune systems, trying to understand evolutionary patterns and molecular mechanisms of these systems but also how to use them for medical applications.
Meet Our Start-ups and iGEM team
Science à la Pelle
Notre objectif est de constituer une grande collection de souches bactériennes des sols de France. Plus ces bactéries sont diverses, et plus nos chances d’y trouver des molécules intéressantes augmentent. Par conséquent, la diversité des échantillons de sols (nature, localisation, composition,…) est un facteur clé pour ce projet.