The Bernheim team’s research focuses on these anti-phage immune systems. We are trying to unders-tand evolutionary patterns and molecular mechanisms of these systems but also how to use them for medical applications. We work at several scales: from compu-tational genomic analysis on thousands of prokaryotic genomes to experimental molecular genetics and diverse microbiology tools.

The Libis team is interested in disco-vering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immuno-suppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites.