WELCOME

to ELiS Laboratories website

The Engaged Life Science (ELiS) Collaboratory

INSERM U1338 (ERL)

ELiS Labs, headed by team leaders Amir Pandi, Vincent Libis (vice director) and Ariel Lindner (director), engages in interdisciplinary research aimed at harnessing fundamental understanding of living systems to face global sustainable development challenges.

We combine expertise in computational biology, systems and synthetic biology and promote open, inclusive, frugal science. Our work is carried out at the INSERM U1338 ERL of INSERM (the French national biomedical institute) and the Sorbonne Université, hosted in and supported by the Learning Planet Institute in Paris.

ELiS combines the expertise of >20 young researchers from >10 nationalities in-house as well as affiliated faculty and alumni across the globe.

Research highlights: Discovery and understanding of novel bioactive microbial metabolites — Natural product discovery from soil bacteria — TerraBacta: global atlas of soil biosynthetic gene clusters — Development of de novo antimicrobial peptides — Engineering bacteria for sustainable bio-production via synthetic organelles – Frugal solutions for low cost detection of infectious agents– Open Medical solutions (e.g., dialysis machine, breast cancer screening)

Discover Our Teams

SEED – Systems Engineering and Evolution Dynamics

The Lindner team’s main efforts rely on years of investment in building an intellectual and experimental framework based on inter-disciplinary approaches, harnessing physics and computer science and on welcoming young researchers to address key questions in Life Sciences with Systems and Synthetic Biology approaches, mainly focusing on Escherichia coli as the simplest (yet still not fully understood) model organism.

UBL – Uncharted Biosynthetic Landscapes

The Libis team is interested in disco-vering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immuno-suppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites.

SynBAI – Synthetic Biology and Artificial Intelligence

The Pandi team research focuses on the development of de novo antimicrobial peptides via a combined approach of machine learning and synthetic biology. Additionally, we use machine learning models to predict and design phase-separating polypeptides and build codon and gene expression language models.

Discover Our Favorite Collaborators

MDM – Molecular Diversity of Microbes

Along this scientific journey, we are glad to count among our favorite collaborators, Aude Bernheim, group leader of the Molecular Diversity of Microbes (MDM) Lab at Institut Pasteur. MDM lab research focuses on anti-phage immune systems, trying to understand evolutionary patterns and molecular mechanisms of these systems but also how to use them for medical applications.

Meet Our Start-ups and iGEM team

Generare Bioscience

A data-driven platform for the discovery of novel drug leads of microbial origins.

baCta

Engineering of Microorganisms for synthetic biology-based natural rubber production.

iGEM

Developping a bio-manufacturable lubricant gel which binds to target proteins on pathogen surfaces.

Science à la Pelle

Notre objectif est de constituer une grande collection de souches bactériennes des sols de France. Plus ces bactéries sont diverses, et plus nos chances d’y trouver des molécules intéressantes augmentent. Par conséquent, la diversité des échantillons de sols (nature, localisation, composition,…) est un facteur clé pour ce projet.

ELiS is recruiting !

Join our teams or hosted Start-ups !
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