to ELiS Laboratories website

The Engaged Life Science (ELiS) Collaboratory

ELiS, headed by team leaders Aude Bernheim, Vincent Libis and Ariel Lindner (unit director), engages in interdisciplinary research aimed at harnessing fundamental understanding of living systems to face global sustainable development challenges.

We combine expertise in computational biology, systems and synthetic biology and promote open, inclusive, frugal science. Our work is carried out at the INSERM U1284 of INSERM (the French national biomedical institute) and the Université Paris Cité, hosted in and supported by the Learning Planet Institute.

ELiS combines the expertise of >20 young researchers from >10 nationalities in-house as well as affiliated faculty and alumni across the globe.

Research highlights: Discovery and understanding of bacterial immune systems — Natural product discovery from soil bacteria — TerraBacta: global atlas of soil biosynthetic gene clusters — Engineering bacteria for sustainable bio-production via synthetic organelles – Frugal solutions for low cost detection of infectious agents– Open Medical solutions (e.g., dialysis machine, breast cancer screening)

Discover Our Teams

SEED – Systems Engineering and Evolution Dynamics

The Lindner team’s main efforts rely on years of investment in building an intellectual and experimental framework based on inter-disciplinary approaches, harnessing physics and computer science and on welcoming young researchers to address key questions in Life Sciences with Systems and Synthetic Biology approaches, mainly focusing on Escherichia coli as the simplest (yet still not fully understood) model organism.

MDM – Molecular Diversity of Microbes

The Bernheim team’s research focuses on these anti-phage immune systems. We are trying to unders-tand evolutionary patterns and molecular mechanisms of these systems but also how to use them for medical applications. We work at several scales: from compu-tational genomic analysis on thousands of prokaryotic genomes to experimental molecular genetics and diverse microbiology tools.

UBL – Uncharted Biosynthetic Landscapes

The Libis team is interested in disco-vering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immuno-suppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites.

Meet Our Start-ups and iGEM team

Generare Bioscience

A data-driven platform for the discovery of novel drug leads of microbial origins.


Engineering of Microorganisms for synthetic biology-based natural rubber production.


Developping a bio-manufacturable lubricant gel which binds to target proteins on pathogen surfaces.

Science à la Pelle

Notre objectif est de constituer une grande collection de souches bactériennes des sols de France. Plus ces bactéries sont diverses, et plus nos chances d’y trouver des molécules intéressantes augmentent. Par conséquent, la diversité des échantillons de sols (nature, localisation, composition,…) est un facteur clé pour ce projet.

ELiS is recruiting !

Join our teams or hosted Start-ups !
Open positions