SEED - Systems Engineering and Evolution Dynamics
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SEED projects
The Lindner team’s main efforts rely on years of investment in building an intellectual and experimental framework based on interdisciplinary approaches, harnessing physics and computer science and on welcoming young researchers to address key questions in Life Sciences with Systems and Synthetic Biology approaches, mainly focusing on Escherichia coli as the simplest (yet still not fully understood) model organism. Focal projects include study of phenotypic variability, aging, evolution of cooperation, probing RNA structure in vivo and RNA scaffolding.
We also develop open and citizen science projects extended from antimicrobial drug discovery and democratizing DNA detection to supporting Open Collaborative Efforts for Autism spectrum Network (OCEAN).
The team is at the core of building the CRI Collaboratory research effort and contributes to developing the CRI undergraduate and graduate programs as well as outreach learning through research programs across the globe. For the past 13 years, the team mentored the Paris Bettencourt iGEM team.
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People
Team leader
Ariel Lindner
Ariel Lindner, co-founder of the CRI/Learning Planet Institute, head of Engaged Life Science (ELiS) and supervisor of the leaders of research teams.
Ariel Lindner is an interdisciplinary Life Science Research Director and heads the Systems Engineering and Evolution Dynamics. Unit of INSERM and Université Paris Cité. He notably develops action research aimed at implementing a set of tools, methods and training courses to better identify, understand and support children according to their needs and strengths.
Administrative and technical Staff
Research Staff
Carla Tous Mayol
PhD
I’m building and engineering synthetic organelles in bacteria using repetitive RNA sequences – called TEARS (Transcriptionally Engineered Addressable RNA Solvent) droplets.
Amir Pandi
Post-doc
My work includes cell-free synthetic biology, genetic circuits design and AI-based development of antimicrobial/phase separating peptides
Antoine Levrier
PhD
Diving into Synthetic Cells, Phage biology from soft chemistry and biophysics perspectives. Loving giant vesicles, cell-free and automation in biology.
Sophie Gontier
Engineer
I am working on a synthetic biological system for screening metabolic drug targets in E. coli. As a proof of concept, we tested our technology for multiple M. tuberculosis targets, as well as targets across multiple pathogenic species.
Alumni
Sanshal Mathew,
Timothee Leblond,
Yann Huon de kermadec, Researcher
Ayan Abukar, PhD student
Monchida Likitphatham,
Mostafa Elraies,
Shahaf Cohen,
Michael Sedbon,
Sandra DelCastillo Delrio, Guy Aidelberg, Engineer
Chloé Prautois, Technician, Sophie Chen, Technician,
Yves Loiseau Marchand,
Vincent Accion, Francisco Javier Quero, Engineer
Publications
2023
2022
2021
2020